Phosphoramidite Market Size to Reach USD 2.14 Billion by 2032 Due to Gene Editing and mRNA Growth – SNS Insider
Expanding demand for oligonucleotide therapeutics and GMP-grade reagents drives steady global market expansion
Austin, Nov. 11, 2025 (GLOBE NEWSWIRE) — Phosphoramidite Market Size & Growth Analysis
According to SNS Insider, the global Phosphoramidite Market was valued at USD 1.18 billion in 2024 and is projected to reach USD 2.14 billion by 2032, growing at a CAGR of 7.78% during the forecast period of 2025–2032.
The strong market growth is fueled by expanding applications of oligonucleotide-based therapeutics, increasing adoption of gene editing tools such as CRISPR, and the surge in mRNA vaccine development. The trend toward custom-modified phosphoramidites, combined with growing demand for GMP-grade reagents, continues to shape the industry. Rapid advances in synthetic biology, genetic testing, and diagnostics have further strengthened the role of phosphoramidites in both commercial and academic research pipelines.
Get free Sample Report of Phosphoramidite Market: https://www.snsinsider.com/sample-request/8264
The U.S. phosphoramidite market was valued at USD 373.15 million in 2024 and is expected to reach USD 670.78 million by 2032, growing at a CAGR of 7.63%. Strong pharmaceutical R&D capabilities, active biotech ecosystems, and supportive FDA policies drive consistent demand. Increased investment in synthetic biology, mRNA, and gene therapy has positioned the U.S. as a leading innovator and exporter of phosphoramidite products.
Major Players in the Phosphoramidite Market Include:
- Thermo Fisher Scientific Inc.
- Integrated DNA Technologies (IDT)
- TriLink BioTechnologies
- Glen Research
- LGC Biosearch Technologies
- ChemGenes Corporation
- Dharmacon (Horizon Discovery)
- GenePharma
- Eurogentec
- Bioneer Corporation
- Biotez Berlin-Buch GmbH
- ATDBio
- Bio-Synthesis Inc.
- Nitto Avecia
- Synthego Corporation
- Sino Biological Inc.
- Aurora Fine Chemicals
- Kaneka Eurogentec SA
Phosphoramidite Market Segment Insights:
By Purity
Standard research grade held a dominant phosphoramidite market share of 35.94% in 2024, due to its popularity in academic, institutional, and early-stage biotech research. GMP-Grade is emerging as the fastest-growing segment in the global phosphoramidite market, registering a CAGR of 8.51% over the forecast period, driven by the growth of oligonucleotide-based therapeutics, including siRNA, ASOs, and mRNA drugs.
By Type
DNA phosphoramidites are the dominant segment in the global phosphoramidite market, with a 36.94% share in 2024, owing to their promiscuous use in diagnostic oligonucleotide synthesis, PCR primers, gene editing, and therapeutic development. The RNA phosphoramidites segment is emerging as the fastest growing with a CAGR of 8.64% in the global phosphoramidite market, fueled by the fast uptake of mRNA vaccines, siRNA therapeutics, and RNA-based diagnostics.
By Application
In 2024, the drug discovery & development dominated the phosphoramidite industry, due to its foundational role in synthesizing therapeutic oligonucleotides, aptamers, and antisense drugs. Diagnostics Development is emerging as the fastest-growing segment in the phosphoramidite market, registering a CAGR of 8.30 % over the forecast period, driven by the increasing requisition of molecular tests including qPCR, NGS, and probe assays.
By End-User
Pharmaceutical & biotechnology companies are the largest segment of the phosphoramidite industry, as a pioneer in oligonucleotide-based drugs, mRNA vaccines, and gene therapies. The academic & research institutes segment is witnessing the highest growth in the global phosphoramidite market, driven by rising genomics, synthetic biology, and molecular diagnostics government and private funding.
Need Any Customization Research on Phosphoramidite Market, Enquire Now: https://www.snsinsider.com/enquiry/8264
Regional Analysis:
Due to its sophisticated biotechnology infrastructure, substantial R&D expenditures, and the presence of significant companies like Thermo Fisher, TriLink, and IDT, the North American region is expected to retain a leading market share of 40.60% of the global phosphoramidite market in 2024.
Asia Pacific emerges as the fastest-growing region with the highest CAGR of 8.47%, owing to the technological advancements in biotech, government funding, and pharma manufacturing capacity are on the up.
Recent Developments:
- In May 2025, LGC expanded its fluorescent phosphoramidite product line, offering improved thermal and chemical stability for use in qPCR probes and RNA detection, enhancing diagnostic assay performance and oligo labeling efficiency.
- In March 2025, IDT launched a new suite of RNA phosphoramidites specifically designed for CRISPR and mRNA synthesis, enabling higher fidelity, stability, and efficiency in therapeutic and genome editing applications.
Exclusive Sections of the Report (The USPs):
- PRODUCTION & SUPPLY CHAIN INSIGHTS – helps you assess global phosphoramidite production patterns, capacity utilization among contract manufacturers and in-house facilities, and the impact of raw material shortages or geopolitical disruptions on supply stability and pricing.
- APPLICATION-LEVEL DEMAND MAPPING – helps you understand demand segmentation across therapeutic oligo synthesis, diagnostics, research, NGS, and gene editing, along with utilization trends among biotech firms, pharma players, and academic institutions.
- QUALITY & COMPLIANCE BENCHMARKS – helps you evaluate market share by purity grade (Research, HPLC-purified, GMP, ultra-pure) and track evolving global standards through FDA, EMA, and PMDA-certified production facilities.
- PRICING & COST STRUCTURE ANALYSIS – helps you analyze price variations by modification type (DNA, RNA, fluorescent, biotin, thiol, etc.), purity grade, and synthesis scale to understand cost per base trends influencing oligonucleotide manufacturing economics.
- REGIONAL DISTRIBUTION & TRADE FLOWS – helps you identify high-demand regions, understand direct-to-lab versus distributor-led sales models, and map key global hubs for production, export, and logistics such as the U.S., Germany, India, and China.
- SUPPLY CHAIN RESILIENCE & RISK INDEX – helps you pinpoint vulnerabilities in raw material sourcing and transport, providing insights into how regulatory shifts or regional instabilities affect the reliability and continuity of the phosphoramidite supply network.
Buy the Phosphoramidite Market Report Now: https://www.snsinsider.com/checkout/8264
Phosphoramidite Market Report Scope
| Report Attributes | Details |
| Market Size in 2024 | USD 1.18 Billion |
| Market Size by 2032 | USD 2.14 Billion |
| CAGR | CAGR of 7.78% From 2025 to 2032 |
| Base Year | 2024 |
| Forecast Period | 2025-2032 |
| Historical Data | 2021-2023 |
| Key Segments | By Type (DNA Phosphoramidites, RNA Phosphoramidites, Labeled Phosphoramidites, Modifier Phosphoramidites, Others)
By Application (Drug Discovery & Development, Diagnostics Development, Others) By Purity (Standard Research Grade, HPLC Purified Grade, GMP-Grade, Custom Grade) By End- user (Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Others) |
| Regional Analysis/Coverage | North America (US, Canada), Europe (Germany, UK, France, Italy, Spain, Russia, Poland, Rest of Europe), Asia Pacific (China, India, Japan, South Korea, Australia, ASEAN Countries, Rest of Asia Pacific), Middle East & Africa (UAE, Saudi Arabia, Qatar, South Africa, Rest of Middle East & Africa), Latin America (Brazil, Argentina, Mexico, Colombia, Rest of Latin America). |
Access Complete Report Details of Phosphoramidite Market Analysis & Outlook: https://www.snsinsider.com/reports/phosphoramidite-market-8264
[For more information or need any customization research mail us at info@snsinsider.com]
About Us:
SNS Insider is one of the leading market research and consulting agencies that dominates the market research industry globally. Our company’s aim is to give clients the knowledge they require in order to function in changing circumstances. In order to give you current, accurate market data, consumer insights, and opinions so that you can make decisions with confidence, we employ a variety of techniques, including surveys, video talks, and focus groups around the world.
CONTACT: Contact Us: Rohan Jadhav - Principal Consultant Phone: +1-315 636 4242 (US) | +44- 20 3290 5010 (UK) Email: info@snsinsider.com
Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. IndiaShorts takes no editorial responsibility for the same.