
Amy Schumer recently opened up about how online comments about her appearance led to her being diagnosed with Cushing syndrome. During an appearance on the Call Her Daddy podcast with Alex Cooper, the comedian revealed that trolls had criticized the “puffiness” of her face, referring to it as “moon face.” At first, Schumer ignored the comments, but things changed when medical professionals began chiming in online, saying, “No, no … something’s really up. Your face looks so crazy.”
Cushing syndrome happens when the body produces too much cortisol, often as a result of certain medications. Schumer explained that while she initially brushed off the possibility, she later realized the connection when she recalled having received steroid injections for her scars. These injections, which she had after her cesarean section in 2019 and liposuction in 2022, contributed to her condition. According to the Mayo Clinic, such steroid treatments can mimic the effects of cortisol, leading to symptoms like facial puffiness.
While promoting her Netflix comedy Kinda Pregnant, Schumer shared how the condition affected her confidence. She admitted, “I was feeling really down on myself before I started filming this movie.” However, a pep talk from her director, Lorraine Caffery, helped lift her spirits. “She told me: ‘You know, I think you look f***ing great.’ I just needed one person to just amp me up,” Schumer recalled. She also shared that the condition eventually resolved itself, saying, “It just has to work itself out.”
In addition to her Cushing syndrome experience, Schumer has been candid about her struggles with weight loss and her brief stint with Ozempic, a drug often used for weight management in people with diabetes. On Watch What Happens Live with Andy Cohen, Schumer admitted to trying Ozempic but found it unsustainable. She joked, “Everyone’s like: ‘Smaller portions,’” adding, “Shut the f*** up. You’re on Ozempic, or one of those things.” She also urged fellow celebrities to be more honest about their use of such medications.