Matthew Perry died from the effects of ketamine, autopsy report reveals

While Matthew Perry’s postmortem report stated that “acute effects of ketamine” were the cause of death, questions remain about the source and nature of his ketamine use. Dr. Bankole Johnson, a well-known neuroscientist, says Perry got the drug illegally for “recreational” purposes.

“It is more likely this was recreational ketamine use,” Johnson said to Page Six. Combining ketamine with buprenorphine, which Perry was also taking for opioid addiction, can be dangerous, as he points out, calling it “a recipe for disaster.”

Perry’s ketamine infusion therapy for depression and anxiety, on the other hand, was documented a week and a half before his demise. Johnson highlights the significance of professional administration for safe ketamine use, emphasizing IV drip for accurate dose management and cautioning against self-administered intranasal methods.

“Intranasal use is generally less safe as it is often self-administered. This also can drive drug-seeking more aggressively.”

Toxicology results indicated that ketamine levels in his system were higher than the average range for monitored surgical settings.

Perry’s death was complicated further by the presence of buprenorphine, which, according to Johnson, can amplify ketamine’s sedating effects and lead to unresponsiveness. It works as a catalyst.

The Los Angeles County Medical Examiner’s report acknowledges the recreational use of ketamine at parties and raves. However, it does not state definitively whether Perry misused or illegally obtained the drug.

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